منابع مشابه
Translation, Pdcd4 and eIF4A
Pdcd4 (programmed cell death 4) has received considerable attention as a tumor suppressor protein in recent years, however, its molecular function is still poorly understood. Pdcd4 is a nuclear-cytoplasmic shuttling and RNA-binding protein, which is involved in the control of translation of specific mRNAs. Pdcd4 interacts with the eukaryotic translation initiation factor eIF4A, an RNA helicase ...
متن کاملCrystal structure of the eIF4A-PDCD4 complex.
Tumor suppressor programmed cell death protein 4 (PDCD4) inhibits the translation initiation factor eIF4A, an RNA helicase that catalyzes the unwinding of secondary structure at the 5'-untranslated region of mRNAs and controls the initiation of translation. Here, we determined the crystal structure of the human eIF4A and PDCD4 complex. The structure reveals that one molecule of PDCD4 binds to t...
متن کاملMutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
Eukaryotic initiation factor (eIF) 4A unwinds secondary and tertiary structures in the 5'-untranslated region of mRNA, permitting translation initiation. Programmed cell death 4 (Pdcd4) is a novel transformation suppressor and eIF4A-binding partner that inhibits eIF4A helicase activity and translation. To elucidate the regions of eIF4A that are functionally significant in binding to Pdcd4, we g...
متن کاملeIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle
Eukaryotic translation initiation factor eIF4A is a DEAD-box helicase that resolves secondary structure elements in the 5'-UTR of mRNAs during ribosome scanning. Its RNA-stimulated ATPase and ATP-dependent helicase activities are enhanced by other translation initiation factors, but the underlying mechanisms are unclear. DEAD-box proteins alternate between open and closed conformations during R...
متن کاملStructural basis for inhibition of translation by the tumor suppressor Pdcd4.
The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G. These interactions are mediated through two MA3 domains on the Pdcd4 molecule and result in inhibition of protein synthesis. We have solved the high-resolution cryst...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.192